Cannabinoid Effects in Multiple Sclerosis
Dr. Michael Duplessie, FRCS Ophth (Glasgow), M.B., B.Ch., L.R.C.P. & S.I., B.A.O., B.A.
Cannabinoid Effects in Multiple Sclerosis
Multiple sclerosis (MS) can be a debilitating disease with limited therapeutic options to halt or reverse disease progression. Despite current treatments, MS patients can still experience deterioration and disability.
The use of cannabinoids has emerged as a potential treatment option for MS due to its ability to modulate the immune system, reduce pain, protect neurons, and promote remyelination.
This systematic review evaluates the efficacy of medical marijuana in MS and experimental animal models. Results from low- and moderate-quality clinical studies showed that a 1:1 CBD/THC mixture as a nabiximols (Sativex®) oromucosal spray reduced spasticity, pain, sleep disturbance, bladder overactivity, and inflammation.
Preclinical studies also demonstrated the potential of cannabinoids to decrease disease severity, motor function impairment, neuroinflammation, and demyelination. Additionally, cannabinoids were found to promote remyelination in vitro and in experimental animal models. Future studies are needed to elucidate the mechanisms of cannabinoid effects on MS and evaluate whether medical marijuana can slow the progression of disability in MS patients over the long term.
Medical Marijuana
Safe & Legal
Throughout my career, I have been dedicated to breaking conventions and helping those in need. My passion for medicine began during my time working in refugee camps in Thailand, and since then, I have made it my mission to provide care and support to those who need it most.
As a pioneer in the field of ophthalmology, I have made numerous contributions and innovations in the field of corneal transplantation and laser surgery. I am comfortable challenging conventions.
I have seen firsthand the positive impact medical marijuana can have on patients struggling with pain and anxiety.
My experiences have shown me that medical marijuana can offer significant benefits with minimal side effects, providing patients with an alternative to traditional pharmaceutical medications. Despite its potential, the government’s stance on marijuana is outdated and in need of revision.
Through my observations, I have seen prescription rates for pain, stress, insomnia, anxiety to name just a few, drastically decrease among patients who have obtained a medical marijuana card, and I believe that this is a testament to its effectiveness.
