Chronic traumatic encephalopathy (CTE) and Marijuana

Dr. Michael Duplessie, FRCS Ophth (Glasgow), M.B., B.Ch., L.R.C.P. & S.I., B.A.O., B.A.

Chronic traumatic encephalopathy (CTE) and Marijuana

Neurodegenerative disorders remain a therapeutic challenge for neurology, with current treatments only able to provide symptomatic relief. However, recent discoveries in the potential of cannabis-based medicines offer promising new avenues for the palliation, arrest, or reversal of associated pathological processes.

While cannabis-based medicines have already demonstrated their efficacy and safety for treating spasticity in multiple sclerosis and certain forms of epilepsy, many challenges remain. This review examines the potential of neutral phytocannabinoids, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the treatment of five currently recalcitrant syndromes: intractable epilepsy, brain tumors, Parkinson’s disease, Alzheimer’s disease, and traumatic brain injury/chronic traumatic encephalopathy.

Recent basic science and clinical investigations have supported the safety and efficacy of cannabis-based interventions for these conditions. Moreover, the polypharmaceutical properties of cannabis botanicals offer distinct advantages over the current single-target pharmaceutical model. Harnessing endocannabinoid mechanisms through direct activity on CB1 and CB2, PPARγ, or 5-HT1A receptors, or even via nutritional approaches utilizing prebiotics and probiotics, may hold the key to successful treatment of these debilitating conditions.

As we continue to unravel the complex pharmacology of cannabis-based medicines, the potential for effective interventional and even preventative treatment of neurological disorders becomes increasingly promising. The future of neurology may well be revolutionized by this versatile and effective plant-based therapy.

Medical Marijuana

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Throughout my career, I have been dedicated to breaking conventions and helping those in need. My passion for medicine began during my time working in refugee camps in Thailand, and since then, I have made it my mission to provide care and support to those who need it most.

As a pioneer in the field of ophthalmology, I have made numerous contributions and innovations in the field of corneal transplantation and laser surgery.  I am comfortable challenging conventions.

I have seen firsthand the positive impact medical marijuana can have on patients struggling with pain and anxiety. 

My experiences have shown me that medical marijuana can offer significant benefits with minimal side effects, providing patients with an alternative to traditional pharmaceutical medications. Despite its potential, the government’s stance on marijuana is outdated and in need of revision. 

Through my observations, I have seen prescription rates for pain, stress, insomnia, anxiety to name just a few, drastically decrease among patients who have obtained a medical marijuana card, and I believe that this is a testament to its effectiveness.

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